5-MeO-DMT, also known as “The God Molecule,” is a powerful psychedelic compound revered for its ability to induce profound spiritual and mystical experiences. It is found in certain plants, toad venom, and synthetic formulations. Below is a breakdown of its benefits and how Psyttraxx provides the safest and most reliable way to buy 5-MeO-DMT online.
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It is naturally-occurring — most predominantly found in a species of toad called Bufo alvarius (AKA the Colorado River Toad or the Sonoran Desert Toad). It’s also common in synthetic form, where it can be smoked, vaped, or insufflated (snorted).
This psychedelic is notoriously fast-acting, but the effects are very short-lived.
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A quick rip of it can take you into a timeless hyperspace where users often report chatting with machine elves. While the experience can feel like a lifetime, most users return to reality within 45 minutes.
Regardless of how short, a trip on it can seriously shift your perspective. Wonderful, terrifying, and sometimes healing, 5-MeO’s potency is an enigma that can humble and inspire.
What’s the Difference Between N,N-DMT & 5-MeO-DMT?
Before going much deeper, let’s be clear — there are several different DMT analogs, each unique from the last.
“DMT” usually refers to N,N-DMT, the active psychedelic ingredient in ayahuasca and changa.
Structurally, N,N,DMT and it are only differentiated by adding an oxygen molecule to its Indole ring.
While some effects of it and N,N,DMT are comparable — i.e., rapid onset and super intense psychedelic experience — the 5-MeO experience transcends the wild, geometric visuals of N,N-DMT.
The effects of it are often conveyed as “oneness,” “non-dual,” or “ineffable.” Ultimately, words can not capture the significance of what it can open us up to. Most users will agree that it pushes the user even further between worlds than N,N,DMT.
What is Bufo alvarius Toad ?
Most people know of 5-MeO-DMT through its amphibian source — the Bufo alvarius toad, also known as the Sonoran Desert toad or Colorado River Toad.
These toads exist in a limited range around Northern Mexico and the Southwestern United States. Here, they spend a great deal of time underground, only emerging at night during the summer rains to breed. This period is “toad season,” and an increasing number of people come to collect the toad’s potent secretions.
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The toad’s popularity is leading to overharvesting, endangering the species in its native habitat.
A recent report documented “rival groups” fighting over the limited number of specimens. Meanwhile, some sell toads online for up to $1,000. There are also concerns about harming the toad when “milking” them of their venom. Bufo excretes venom as a milky white substance from parotoid glands on its head as a defense mechanism.
The venom is then dried for transport and smoking. The venom contains a cocktail of other (potentially) active compounds, such as bufotenin (5-HO-DMT), that are believed to contribute to the effects of it through a concept called the entourage effect
Sublingual 5-MeO-DMT And Oral
There’s been some confusion over whether or not it is orally-active or not.
Ethnobotanist Richard Evans Schultes first documented oral preparations, which were later investigated by Dennis Mckenna . However, it took some time to unravel the mystery, as Dennis couldn’t replicate the effects witnessed in the Amazon. Pioneering chemist Sasha Shulgin also wrote it was inactive orally in TiHKAL.
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However, in later years, Jonathan Ott documented oral activity with it in a capsule of 30 mg. The reported effects were not nearly as potent. Ott further experimented with the addition of harmala alkaloids (a potentially dangerous mix we do not recommend) to achieve greater psychoactive effects.
The 5-MeO-DMT Synthetic
With the rarity of the toad and Amazonian snuffs, synthetic of it use has blossomed. It was first synthesized by Japanese chemists Toshio Hoshino and Kenya Shimodaira in 1936 from Anadenanthera peregrinhea seeds.
Many buy the compound from online research chemical vendors and some chemical manufacturers.
Synthetic of it comes in either a white to yellow or orange crystalline powder.
5-MeO-DMT Dosage
The effective dose of it depends on the delivery method — smoked, vaped, snorted, swallowed, injected, or taken rectally.
The form also matters — toad venom, synthetic, snuff, or oral preparation.
Administration of snuffs sourced from the Amazon should be done by a trained practitioner, as dosage can vary depending on the specific plants and preparation method used.
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In Tryptamine Palace, James Oroc notes that finding an optimal dose when smoking is best adjusted in 2 mg increments. He also explains that finding your “minimum effective dose” helps you actually remember the transcendental experience. This is because it is easy to smoke too much, get stuck in a “white hole,” and have no recollection of what happened
1. Colorado River Toad Venom Dosage
The standard dose range for raw Bufo alvarius toad venom is between 10 and 60 mg, smoked or vaped.
Bufo toad venom alkaloid concentration varies. Alexander Shulgin reported in TiHKAL that the venom could contain up to 15% OF it
Other sources mention a range of 10-30%. In short, potency is highly variable, and individual responses to bufo will vary greatly. Always start small, work your way up, and find an experienced practitioner when working with toad venom.
2. What Is Synthetic 5-MeO-DMT Dosage ?
Synthetic 5-MeO is often smoked but is also sometimes snorted, boofed, and taken orally or sublingually. Smoking will come on fast and end quickly. Snorting, plugging, and oral routes have a gentler, slower come-up and will last longer.
When deciding which access route to take, consider if the substance is HCl or freebase. Most favor HCl for snorting and freebase for smoking. Snorting will burn (freebase a lot), and online reports suggest rectal might too. Both methods are known to cause nausea.
| Dose Level | Smoked/Vaped | Snorted |
| Threshold | 1-5 mg | 3-5 mg |
| Low Dose | 5-7 mg | 5-10 mg |
| Standard Dose | 8-12 mg | 8-15 mg |
| High Dose | 13-20 mg | 10-25 mg |
3. Methods of Administration of Synthetic 5-MeO-DMT
How Does 5-MeO-DMT Feel Like?
The effects of it depend on the method of consumption and whether or not you “breakthrough.”
Threshold doses of it bring a brightness to the world, what Jonathan Ott calls “a magical varnish” over reality. Fractal geometry can be entertaining. Some people experience a significant “body load,” a sensation of heaviness or amplified gravity. Alexander Shugin described this as “blood turning into cement.”
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At higher doses, one leaves the body and everyday reality behind. A common theme is merging with white light, the universe, God, or love. Some people encounter entities, spirits, and ancestors. Many people will hear a sound associated with high-dose DMT (some consider it “om,” the sound of creation). Perception of time may change or cease to exist altogether. All this can carry great emotional significance and release.
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It can be incredibly beautiful but is extremely intense. Being able to “let go” is helpful but can be challenging in the face of such a potent experience. The sense of losing control can be very humbling. Deep breaths and surrendering make the experience smoother, along with compassion for yourself for trying one of the most powerful psychedelics known.
Skilled facilitators can also help you prep and integrate for it.
Common Features of 5-MeO-DMT include:
- Fractals
- White light
- “The Sound”
- Spirits, God, Ancestors, Love
- Oneness, ego-dissolution, out-of-body
- Overwhelm, losing control, “too much”
- Timelessness
How Long Does 5-MeO-DMT Last Long ?
it is notoriously short-acting. This has led many to refer to this drug as a “business trip.” Most intake methods don’t last longer than about 45 minutes. However, there’s some nuance here depending on how much you took and how you took it.
1. Vaped or Smoked
Smoked or vaporized, it takes effect within seconds.
At high enough doses, the sense of disconnect from one’s body lasts 5-20 minutes.
After this peak, the effects rapidly disappear, and within 45 minutes to an hour, full sobriety settles in.
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The body metabolizes it very rapidly, so you will never get stuck in it mode.
While the effects don’t last long, it’s best to give yourself some time to rest and process it, as the experience can be a lot to take in.
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2. Swallowed or Snorted
When snorted, the effects begin acting within minutes, peaking around 10-20 minutes. After 45 minutes, the effects lessen, and the entire experience lasts about an hour for most people.
Depending on the preparation, particularly with various snuffs, some people experience lingering effects for up to three hours later.
Oral consumption is similar but with a 30-minute delay. The effects kick in about 40–50 minutes after taking it, remain active for about 20-30 minutes, and taper off over the next hour. Some lingering effects may remain for several hours.
How Strong Are Other Psychedelics Compared To 5-MeO-DMT ?
It is 4-5 times stronger than N-N,DMT — according to Jonathan Ott in Pharmacotheon.
It’s also stronger than most other psychedelics. Even high doses of psilocybin (the active ingredient in magic mushrooms) are about 10% as strong as a standard dose of it. Mescaline (the active ingredient in Peyote and San Pedro Cacti) is about the same.
Even very powerful psychedelics like salvinorin A (the active ingredient in Salvia divinorum) are notably milder in the depth of experience.
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Technically speaking, the lysergamide family (LSD, AL-LAD, PRO-LAD, LSZ, ETH-LAD, 1P-LSD, and others) are stronger than it, but only when you compare the dose. The effects of these compounds are far less intense than it.
The standard oral dose range for lysergamides like LSD is between 80 and 120 mcg. Compare this to around 20 or 30 mg for it. This makes LSD significantly stronger, but even in very high doses, LSD doesn’t completely blast apart our perceptions of reality and time the way it can.
Safety Of 5-MeO-DMT
While you’re unlikely to die from an overdose on it, it can still be dangerous if misused.
The usual psychedelic cautionary notes apply — people with physical health problems like heart conditions might be at risk. Those with mental health concerns like schizophrenia, behavior, or other diagnoses should not use it. Consult with a trusted professional if you’re uncertain.
What Are 5-MeO-DMT Side Effects ?
Side effects like seizures, self-harm, violent physical releases, and psychosis have occurred in some people without warning. There are some reports of people dying from choking on vomit after taking it by themselves.
Abuse And Addiction
Addiction is also rare but not unheard of — especially with the advent of DMT vape pens, many users find themselves puffing on DMT compulsively. This can significantly increase the risk of mental health disorders like psychosis or hallucinogen-persisting perception disorder (HPPD).
What Are The Dangers of Tripping Solo on 5-MeO-DMT ?
Using it without a tripsitter is not recommended. During the experience, a loss of bodily control is common. Having someone nearby to protect you from harm while under the effects is a necessity. This person should be a trained facilitator who knows CPR.
Prescription Drug Interactions
Do not mix it with prescription drugs, including SSRIs (selective serotonin reuptake inhibitors), MAOIs (monoamine oxidase inhibitors), or other antidepressants or antipsychotics.
Anyone mixing it with harmala alkaloids should be extremely careful, as these can also cause potentially lethal consequences.
What is Overdose Of 5-MeO-DMT
While rare, an overdose on it is possible, and there have been reports of this happening in the past. Shulgin includes a harrowing account in THiKAL of needing to resuscitate someone who stopped breathing after taking too much. There are also concerns about mixing it with ayahuasca, with at least one death reported in the literature.
Does 5-MeO-DMT Have Long Term Side Effects ?
Long-term side effects from it are rare and can normally be avoided through intentional use and adequate integration following the experience.
One of the most common persisting side effects is anxiety or a vague sense that “something” is wrong.
Difficulty sleeping or “grounding” is also not uncommon after taking 5-MeO. Some practitioners encourage eating heavy foods for a few weeks after the experience to offset this effect.
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There is also the potential for flashbacks, known as “reactivations.” This isn’t a rumor; it’s well documented in research, but the exact cause is unknown. Some subjects report quick flashes, while others report a full-blown experience. Reactivations can last anywhere from a few seconds to a week.
How To Test Purity OF 5-MeO-DMT
The Erlich and Hoffman regent tests are the best way to test it samples for purity.
It’s always wise to test a sample of your drugs BEFORE you take them. But remember that testing doesn’t guarantee safety or purity and is best used to rule out certain dangerous compounds.
The Erlich test cannot confirm the presence of it but is helpful to distinguish if you do, in fact, have an indole (and not something dangerous like an N-Bombs).
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A successful test will turn a purplish color; view the video here.
To further distinguish between tryptamines, a Hoffman reagent test works well. For example, if you are unsure if you have N,N-DMT, orit. For it, the Hoffman test will turn green. If it is N,N,DMT, a yellowish color will appear instead.
Legality Of 5-MeO-DMT
The legality of 5-MeO-DMT varies. It was not banned alongside other psychedelics in the 70s as it was not as popular then. However, since its reputation has grown, it has been a Schedule 1 substance in the United States since 2011.
Other countries have yet to ban this substance — most notably Canada, where 5-MeO-DMT is readily sold online and in some dispensaries.
Notable countries for access (though not necessarily legal) include:
How Does 5-MeO-DMT Works ?
It is a serotonergic psychedelic. This means it primarily binds to the serotonin receptors — most notably the 5HT1A, 5HT2A, and 5HT2C receptors.
It has a methoxy group attached to its primary ring structure (known as an indole ring). This methoxy group may create a higher receptor binding affinity than its DMT relatives. This is why it works so rapidly and powerfully compared to other forms of DMT.
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Some studies also show interesting and promising data regarding the use of 5-MeO DMT for various mental health conditions, including:
- Anxiety
- Depression
- Immunomodulation
- Inflammation
- Life satisfaction
- Mindfulness
- Neuroendocrine effects
- Obsessive-compulsive disorder
- PTSD
- Stress
- Substance use disorder
FAQS:
If we still haven’t answered your question, email us at contact@psyttraxx.com
1. Can Colorado River Toads Be Lick ?
You can lick toads, but don’t expect to get high, only sick. There are hundreds of species of Bufo toads, but we only know that Alavruis contains enough alkaloids for a psychedelic experience. While it’s possible to eat toad venom for psychoactive effects, keep in mind that toads secrete venom as a defense mechanism — it’s supposed to make you feel uncomfortable. There are reports of animals and children having fatal responses to bufo venom.
2. 5-MeO-DMT Retreats Where to find them?
While unscheduled in countries like Canada or parts of Europe, it may be difficult to find retreats openly offering 5-MeO-DMT. Mexico and some parts of South America have fairly open use of it with a growing number of retreat options. Some practitioners perform individual and group it ceremonies. Be sure to vet any practitioner thoroughly.
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Depending on your location, it is possible to buy 5-MeO-DMT online with PSYTTRAXX. There are established options in Canada USA and some parts of Europe is www.psyttraxx.com but be aware that various jurisdictions will treat unscheduled drugs differently. Unscheduled is more of a “grey area” than being legal or decriminalized, so research carefully.
4. Does 5-MeO-DMT Cause Flashbacks?
Yes, it does sometimes have persisting effects called reactivations. While this is not technically considered the same as hallucination persisting perception disorder (HPPD), which is a serious medical condition, a significant number of people have reported having brief glimpses or very strong feelings that continued for some time after it. Exactly why this happens is unclear and may relate to too-high or repeated uses in one sitting.
5. Where Can I Find More 5-MeO-DMT Resources?
With the popularity of psychedelics on the rise, it resources and organizations have been showing up. You can get the best quality 5-MeO-DMT online at PSYTTRAXX. Some helpful educational platforms and help to find facilitators and integration practitioners include:
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9. Can I test my 5-MeO-DMT to see if it’s safe to take?
Testing your 5-MeO-DMT is always good practice even when you trust your supplier. Reagent test kits from Bunk Police can identify hundreds of adulterants and substitutes—offering peace of mind and potentially saving your life.
The Hofmann and Mecke reagents, for example, can help identify real it. Simply place a tiny amount of it into a sterile test tube or onto a sterile white ceramic surface and add a few drops of the reagent. Then check the color change (or lack thereof) against the supplied spectrum booklet.
10. Can 5-MeO-DMT cause psychological trauma?
Most people find it experience overwhelming. Consensus reality, the physical environment, body, and self tend to fall away and behavior can become irrational. While long-term psychosis seems improbable, it may take some time to fully recover from the it experience.
After higher doses, some users have reported persistent psychological difficulties, including paranoia and the subtle (but controllable) resurfacing of effects, that can last for several weeks.
“White-outs” and memory suppression are also common during the it trip itself, negatively affecting users’ ability to form memories of the altered state.
11. Are there risks?
Taken in the presence of a sitter with no other drugs or contraindicated medications (like MAOI antidepressants), it appears to be relatively safe. That said, persistent anxiety has been reported after just one use, along with sleep disruption and panic attacks. To help minimize the risks, it’s a good idea to start with low, precisely measured doses, and have an experienced sitter present.
Alternatively, you may wish to be in the presence of a more actively engaged facilitator, or ‘practitioner’—a it specialist trained to guide and help integrate your experience. Click here for in-depth tips on how to choose the right person or group for the job and what you should expect them to do.
12. What should I do in the event of a 5-MeO-DMT overdose?
It overdose reports indicate a risk of breathing difficulties and loss of consciousness. If this happens, roll the person onto their side and call the emergency services, keeping them calm until paramedics arrive. A responsible, trained sitter may also need to provide mouth-to-mouth resuscitation after checking the airway is clear.
13. What’s the safest way to take it?
There is no entirely safe way, but vaporizing or smoking it powder is by far the most tried and tested. The onset of effects is shorter than with insufflated or sublingual use. However, some people experience chest pains from the smoke. Others experience no effects whatsoever and prefer intravenous or intramuscular injections. These induce rapid, intense effects even at low doses. Swallowing the drug isn’t recommended due to safety concerns and it’s often ineffective anyway.
14. Can I microdose with 5-MeO-DMT?
As people’s reactions vary immensely, it’s hard to give a reliable microdose range. Some have felt profound effects on less than a threshold dose, while others experience only mild effects from a moderate dose.
15. Can I develop a tolerance?
Yes, tolerance develops almost immediately and takes two hours to return to baseline. There is no cross-tolerance with other psychedelics.
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5-Meo-DMT Buy or 5-methoxy-N, N-dimethyltryptamine is a ring-substituted
indole alkaloid molecule of the tryptamine class.